Neuroprotection: Research papers
- Low serum uric acid concentration in Parkinson's disease in southern Spain
This study produced consistent findings that UA might have a protective effect against Parkinson's disease and could influence its clinical progression.
12 May 2012
- Parkinson's disease, insulin resistance and novel agents of neuroprotection
The authors' aim is to highlight this converging evidence and stimulate further hypothesis-testing studies specifically with reference to the potential development of novel neuroprotective agents in Parkinson's disease.
17 February 2012
- Environmental tobacco smoke and Parkinson's disease
Compared with never active or passive tobacco smokers, we observed reduced Parkinson's disease risks for ever passive only smokers (OR, 0.34; 95% CI, 0.160.73), similar to those for ever active smokers (OR, 0.35; 95% CI, 0.170.73)
15 February 2012
- Upcoming treatments in Parkinson's disease, including gene therapy
Other gene therapies, in various stages of human clinical trials, include gene transfer for the production of trophic factors, for aromatic amino acid decarboxylase alone, and most recently, a lentiviral vector transfer of an enzymatic dopamine factory consisting of three essential enzymes required for production for this neurotransmitter.
01 January 2012
- Parkinson's Disease Therapeutics: New Developments and Challenges Since the Introduction of Levodopa
It appears that the combination of early PD nonmotor symptoms with imaging of the nigrostriatal dopaminergic system offers a promising path toward the identification of PD biomarkers, which, once characterized, will set the stage for efficient use of neuroprotective agents that could slow down and alter the course of the disease
01 January 2012
- The Neuroprotective Disease-Modifying Potential of Psychotropics in Parkinson's Disease
The most promising neuroprotective investigative priorities will involve disease-modifying trials of the safest agents alone or in combination to capture salutary effects on H3 histone deacetylase, gene transcription, glycogen synthase kinase-3, α-synuclein, reactive oxygen species (ROS), reactive nitrogen species (RNS), apoptosis, inflammation, and trophic factors including GDNF and BDNF.
01 January 2012
