Motor fluctations and Parkinson's: Research papers

Inhibition of phosphodiesterases rescues striatal long-term depression and reduces levodopa-induced dyskinesia The aim of the present study was to evaluate the role of the nitric oxide/cyclic guanosine monophosphate pathway in corticostriatal long-term depression induction in a model of levodopa-induced dyskinesia in experimental parkinsonism. 22 December 2010
Levodopa-induced dyskinesias in patients with Parkinson's disease: filling the bench-to-bedside gap the long-term use of this dopamine precursor is complicated by highly disabling fluctuations and dyskinesias. Although preclinical and clinical findings suggest pulsatile stimulation of striatal postsynaptic receptors as a key mechanism underlying levodopa-induced dyskinesias, their pathogenesis is still unclear. 01 November 2010
Low-protein and protein-redistribution diets for Parkinson's disease patients with motor fluctuations: A systematic review The American Academy of Neurology suggests advising the redistribution of daily protein meal content to every Parkinson's disease (PD) patient with motor fluctuations during levodopa treatment. However, no comprehensive evaluation of this complementary therapy has been performed 28 July 2010
Deep brain stimulation plus best medical therapy versus best medical therapy alone for advanced PD (PD SURG trial) At 1 year, surgery and best medical therapy improved patient self-reported quality of life more than best medical therapy alone in patients with advanced Parkinson's disease. These differences are clinically meaningful, but surgery is not without risk and targeting of patients most likely to benefit might be warranted. 01 June 2010
Dopaminergic modulation of striato-frontal connectivity during motor timing in Parkinson's disease Patients with Parkinson's disease experience motor and perceptual timing difficulties, which are ameliorated by dopaminergic medication. We investigated the neural correlates of motor timing in Parkinson's disease, including the effects of dopaminergic medication on patterns of brain activation. 16 March 2010
Enteral levodopa/carbidopa gel infusion for the treatment of motor fluctuations and dyskinesias in advanced Parkinson's disease The infusion provides smooth plasma levodopa levels, more continuous dopaminergic stimulation and effective treatment of motor complications. 01 October 2006

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