Wearing-off and Parkinson's: Research papers

Dopaminergic modulation of striato-frontal connectivity during motor timing in Parkinson's disease Patients with Parkinson's disease experience motor and perceptual timing difficulties, which are ameliorated by dopaminergic medication. We investigated the neural correlates of motor timing in Parkinson's disease, including the effects of dopaminergic medication on patterns of brain activation. 16 March 2010
Long-term antidyskinetic efficacy of amantadine in Parkinson's disease This study was performed to assess the long-term antidyskinetic effect of amantadine in PD patients. The findings argue for long-term antidyskinetic efficacy of amantadine in PD patients with LID's. 02 March 2010
Orodispersible sublingual piribedil to abort OFF episodes A single dose placebo-controlled, randomized, double-blind, cross-over study. S90049, a novel sublingual formulation of the non-ergoline D(2)-D(3) agonist piribedil, has a pharmacokinetic profile promising to provide rapid relief on motor signs in Parkinson's disease (PD). 12 January 2010