Apathy and Parkinson's: Research papers

Apathy in Parkinson's disease: Diagnostic and etiological dilemmas Exploratory analysis of the primary endpoint for 100 mg/day demonstrated that the addition of safinamide to a stable dose of DA improves motor symptoms in early PD and warrants further investigation. 11 January 2012
Neurocognitive Correlates of Apathy and Anxiety in Parkinson's Disease Our findings demonstrated a differential association of apathy and anxiety to cognition in PD. 28 December 2011
Apathy and impulse control disorders in Parkinson's disease: A direct comparison Conclusion: Apathy and ICDs may be on a common behavioral spectrum in PD. Both are associated with significant psychiatric morbidity supporting shared underlying pathology. 31 October 2011
Impact of apathy on health-related quality of life in recently diagnosed Parkinson's disease: The ANIMO study Apathetic PD patients showed EuroQol-5D index scores significantly lower than those without apathy (0.64 vs 0.83). In an adjusted model, apathetic PD patients were 2.49 times more likely to have lower HRQOL than nonapathetic patients (odds ratio, 2.49; 95% confidence interval, 1.494.15, P < 0.01). 20 July 2011
Validation of diagnostic criteria for apathy in Parkinson's disease The recently proposed diagnostic criteria for apathy are useful in clinical practice and in research with PD patients with and without cognitive impairment 21 September 2010
Non-motor dopamine withdrawal syndrome after surgery for Parkinson's disease: predictors and underlying mesolimbic denervation Apathy has been reported to occur after subthalamic nucleus stimulation, a treatment of motor complications in advanced Parkinson's disease. We carried out a prospective study of the occurrence of apathy and associated symptoms, predictors and mechanisms in the year following subthalamic stimulation. 22 March 2010

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