Compulsive behaviour and Parkinson's: Research papers

Genetic variant of HTR2A associates with risk of impulse control and repetitive behaviors in Parkinson's disease Analysis data support a possible contribution of genetic variation in the HTR2A to the susceptibility to impulse control and repetitive behaviors in Parkinson's disease. 01 January 2012
Apathy and impulse control disorders in Parkinson's disease: A direct comparison Conclusion: Apathy and ICDs may be on a common behavioral spectrum in PD. Both are associated with significant psychiatric morbidity supporting shared underlying pathology. 31 October 2011
Are there ethnic differences in impulsive/compulsive behaviors in Parkinson's disease? Of all the studied patients, 15 patients confirmed to have ICB (lifetime prevalence: 5.60%), 3 (1.12%) were diagnosed to have DDS, 1 (0.37%) punding, 4 (1.49%) PG, 8 (2.99%) HS, 1 (0.37%) BE, 0 (0%) CS. OCD was found in one patient (0.37%). 31 October 2011
Reward processing abnormalities in Parkinson's disease These results provide evidence that modulation of motor cortex inhibition by reward is mediated by dopamine signaling and that the physiological state of the motor cortex changes with risk-taking tendency in patients on pramipexole. 15 July 2011
Dopamine agonists and risk: impulse control disorders in Parkinson's disease Study results provide a potential explanation of why dopamine agonists may lead to an unconscious bias towards risk in susceptible individuals. 02 May 2011
Cue-induced striatal dopamine release in Parkinson's disease-associated impulsive-compulsive behaviours The heightened response of striatal reward circuitry to heterogeneous reward-related visual cues among a group of patients with different impulsive-compulsive behaviours is consistent with a global sensitization to appetitive behaviours with dopaminergic therapy in vulnerable individuals. 01 April 2011

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