Deep brain stimulation: Research papers

Treatment of motor and non-motor features of Parkinson's disease with deep brain stimulation Some non-motor symptoms improve after DBS, partly because of motor benefit or reduction of drug treatment, and partly as a direct effect of stimulation. More evidence on the effects of DBS on non-motor symptoms is needed and specifically designed studies are warranted. 01 May 2012
Deep brain stimulation and cognitive decline in Parkinson's disease: a clinical review On the other hand it has been observed that certain aspects of cognitive performance may decline after DBS, namely when the therapeutic target is the widely used subthalamic nucleus. These are important pieces of information for patients, their families, and health care professionals. This manuscript reviews these aspects and their clinical implications. 26 April 2012
Subthalamic neuronal responses to cortical stimulation Conclusions: To prevent seizures the current density should be lowered, so that motor cortex stimulation-evoked responses can be safely used during deep brain stimulation surgery. 15 March 2012
Combined pedunculopontine-subthalamic stimulation in Parkinson disease These findings suggest that concomitant low frequency stimulation of PPN and cZi regions induces additive brain activation changes and provides improved control of PD symptoms when medicated. 07 March 2012
Subthalamic nucleus deep brain stimulation outcome in young onset Parkinson's disease: a role for age at disease onset? In this study, the issue of whether YOPD might represent a long term positive predictive factor for STNDBS was addressed, comparing follow-up data for 20 YOPD and 40 n-YOPD patients (20 treated after <15 years of disease duration and 20 treated after 15 years of disease duration). 01 March 2012
Change in fatigue after bilateral subthalamic nucleus deep brain stimulation for Parkinson's disease Conclusion: Changes in fatigue severity were not observed in the study cohort as a whole, but there were changes in fatigue on an individual level. These changes appear to be related to the effects of STN DBS on motor improvement and mood. 15 February 2012

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