Stem cell therapy: Research papers

Induction of A9 dopaminergic neurons from neural stem cells improves motor function in an animal model of Parkinson's disease This demonstrates that given the correct signals, NSCs can be induced to become dopaminergic neurons that can differentiate into the correct nigrastriatal phenotype required for the treatment of Parkinson's disease. 01 March 2008
Partial recovery of dopaminergic pathway after graft of adult mesenchymal stem cells in a rat model of Parkinson's disease These data demonstrate that graft of adult mesemchymal stem cells reduces behavioral effects induced by 6-hydroxydopamine lesion and partially restores the dopaminergic markers and vesicular striatal pool of dopamine. This cellular approach might be a restorative therapy in Parkinson's disease. 01 March 2008
Will Stem Cell Biology Generate New Therapies for Parkinson's Disease? Three papers recently published in Nature Medicine provide the most detailed analyses of fetal midbrain grafts in patients with Parkinson's disease. Some of the results are surprising and suggest a new wave of questions aimed at both the value of cell therapy and the nature of the disease itself. 01 June 2008
Noggin Enhances Dopamine Neuron Production from Human Embryonic Stem Cells and Improves Behavioral Outcome After Transplantation The study concludes that Noggin promotes dopamine neuron differentiation and survival from human and mouse embryonic stem cells. Disclosure of potential conflicts of interest is found at the end of this article. 01 November 2008
What are the prospects of stem cell therapy for neurology? This article examines some key problems that need to be resolved before the promise of stem cells for regenerative neurology can be realised. 28 November 2008
Prospects of stem cell therapy for replacing dopamine neurons in Parkinson's disease Moreover, a clinically competitive cell therapy for PD will require better criteria for patient selection, improved functional efficacy of grafts by a tailor-made transplantation procedure providing optimum repair of the patient's DA system and strategies to prevent dyskinesias and tumor formation. 12 April 2009

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