Surgical treatments for Parkinson's: Research papers
- Parkin controls dopamine utilization in human midbrain dopaminergic neurons derived from induced pluripotent stem cells
The results suggest that parkin controls dopamine utilization in human midbrain DA neurons by enhancing the precision of DA neurotransmission and suppressing dopamine oxidation. Thus, the study provides novel targets and a physiologically relevant screening platform for disease-modifying therapies of PD.
07 February 2012
- Subthalamic deep brain stimulation with a constant-current device in Parkinson's disease: an open-label randomised controlled tr
Interpretation: Constant-current DBS of the subthalamic nucleus produced significant improvements in good quality on time when compared with a control group without stimulation. Future trials should compare the effects of constant-current DBS with those of voltage-controlled stimulation.
01 February 2012
- Changes in cognitive-emotional and physiological symptoms of depression following STN-DBS for the treatment of Parkinson's
Preliminary results suggest that the motor improvement often observed in patients with PD following bilateral STN-DBS may be partially offset by an increase in affective-cognitive symptoms of depression.
01 January 2012
- Upcoming treatments in Parkinson's disease, including gene therapy
Other gene therapies, in various stages of human clinical trials, include gene transfer for the production of trophic factors, for aromatic amino acid decarboxylase alone, and most recently, a lentiviral vector transfer of an enzymatic dopamine factory consisting of three essential enzymes required for production for this neurotransmitter.
01 January 2012
- Parkinson's Disease Therapeutics: New Developments and Challenges Since the Introduction of Levodopa
It appears that the combination of early PD nonmotor symptoms with imaging of the nigrostriatal dopaminergic system offers a promising path toward the identification of PD biomarkers, which, once characterized, will set the stage for efficient use of neuroprotective agents that could slow down and alter the course of the disease
01 January 2012
- Subthalamic neuronal responses to cortical stimulation
Conclusions: To prevent seizures the current density should be lowered, so that motor cortex stimulation-evoked responses can be safely used during deep brain stimulation surgery.
30 December 2011
